We thought we should give you some lesser promoted, but notable facts about resveratrol. We know most people don’t have lots of spare time to read through articles like these or to concentrate on the science, so we will keep it short and sharp!

Resveratrol is a polyphenol found in red wine, grapes, berries, mulberries, peanuts and rhubarb. It is suggested to provide a variety of benefits that ultimately may reduce the stress on your heart and brain, greatly enhance antioxidant capacity and reduce your chances of diabetes. 

The way that resveratrol reduces stress on your heart is through it’s ability to increase nitric oxide production, which causes your blood vessels (arteries and veins) to relax and expand. Blood can therefore flow much more freely around your body and deliver much needed oxygen and nutrients to your muscles and cells.

From a science point of view (excuse the nerd talk for a minute), it is believed this may be due to the activation of silent mating type information regulation 2 homolog (SIRT1) gene which can up-regulate expression of transcription factor Krüpple-like factor 2 and eNOS in resveratrol-treated human vascular endothelial cells. Up-regulation of SIRT1 expression, activated by resveratrol, is also said to improve insulin sensitivity.

What can improving insulin sensitivity do? You guessed it; improve blood sugar control and prevent diabetes. But wait, there’s more. Previous research suggests that resveratrol can help improve the blood flow to the brain, and may also improve the health of the blood vessels in your brain. This is critical for preventing cerebrovascular disease, dementia, and slowing the natural rate of cognitive decline.

Kennedy and colleagues treated 22 healthy adults in 2009 with two doses of resveratrol (250 and 500 mg) or placebo on two separate days. The authors found that resveratrol consumption resulted in dose-dependent increases in blood flow to the brain and also improvements in performances on brain testing tasks!

Summary:

Resveratrol is safe with no defined toxic side effects at doses less than 1000 mg per day. Most resveratrol products on the market do not have more than 200 mg in their daily recommended doses. Why you should take it? Avoid missing out on these 4 critically important potential benefits:

  • Reduce chances of cardiovascular disease
  • Maintain brain health and slow cognitive decline
  • Improve insulin sensitivity
  • Improve antioxidant capacity

Have you got any science articles for me?

Sure do. Here are a few to sink your teeth into:

1. Markus M, Morris B. Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical Interventions in Aging. 2008;3(2):331-9.
2. Li H, Xia N, Förstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 2012;26(2):102-10.
3. Gracia-Sancho J, Villarreal G, Zhang Y, García-Cardeña G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovascular Research. 2010;85(3):514-9.
4. Arrick DM, Sun H, Patel KP, Mayhan WG. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Am J Physiol Heart Circ Physiol. 2011;301(3):H696-703.

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